Anna was conceived in vitro to be the genetic match to her older sister Kate who was diagnosed with acute promyelocytic leukemia when she was 2 years old.
When Anna was born, her cord blood was donated to her sister, but when the leukemia returned, she then had to donate blood and bone marrow. When Kate's kidneys fail, Anna is expected to donate one of her own, but she hires a lawyer to be medically emancipated from her parents and gain the right to make the decision herself.
'
My sister's keeper' examines what it means to be a good parent, a good sister, a good person. What is the limit of what one will do to save their child’s life?
Director Nick Cassavetes, who co-wrote the script for the up and coming movie adaptation of the book, along with Jeremy Leven (writer of Cassavetes' “The Notebook”), traces this conflict through flashbacks from various characters' perspectives: bulldog matriarch Sara (Cameron Diaz), whose priority is preserving Kate's life at all costs; father Brian (Jason Patric), who's patient and supportive no matter what; only son Jesse (Evan Ellingson), who feels lost in the shuffle; and Kate and Anna themselves.